DNA damage by respiratory quartz particle in rat lung epithelial cells: mechanisms and consequences in vitro
نویسنده
چکیده
.....................................................................................................................6 Zusammenfassung ....................................................................................................8 Chapter 1: General Introduction................................................................................................11 Chapter 2: Inhibition of the mitochondrial respiratory chain function abrogates quartz induced DNA damage in rat lung epithelial cells..................................................35 Chapter 3: Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in rat lung epithelial cells.............58 Chapter 4: Summary and General Discussion.........................................................................79 Acknowledgements..................................................................................................87 Curriculum Vitae.......................................................................................................89
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DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation.
Respirable quartz has been classified as a human lung carcinogen (IARC, 1997). However, the mechanisms involved in quartz-induced carcinogenesis remain unclear. The aim of the present study was to investigate acute DNA damage in epithelial lung cells from rats exposed to quartz. Since surface reactivity is considered to play a crucial role in the toxicity of quartz, the effect of surface modify...
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